Centre for Transplantation (BMT) and Cellular Therapy
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Blood and marrow transplantation (BMT) is a highly sophisticated, life saving medical procedure that offers hope to patients with various life-threatening blood disorders, immune system diseases, and certain types of cancer. The primary goal of this treatment is to replace a patient’s diseased or damaged bone marrow with healthy stem cells, which can then regenerate a new, functional blood and immune system.
Blood and Marrow Transplantation (BMT)
Paediatric
- Leukemias, lymphomas, sickle cell disease, thalassemia, immunodeficiencies.
- Growth impacts, long-term effects, fertility preservation.
- Siblings preferred, cord blood common.
- Often reduced-intensity to minimize long-term effects.
- Family-centered care, school reintegration.
Common indications
Key considerations
Donor selection
Conditioning
Focus
Adult
- Leukemias, multiple myeloma, lymphomas, myelodysplastic syndromes.
- Comorbidities, previous treatments, work/family responsibilities.
- Matched unrelated and haploidentical donors more common.
- Myeloablative or reduced-intensity based on patient factors.
- More severe GVHD, focus on managing late effects and quality of life.
Common indications
Key considerations
Donor selection
Conditioning
Focus
Bone Marrow Function
- The bone marrow transplant procedure is a painless process that doesn't require anesthesia. Stem cells are infused into the patient's body through a catheter surgically placed in a chest vein. Following the transplant, patients are closely monitored to prevent infections and complications.
- Doctors provide guidance on medications, diet, and lifestyle changes. The recovery process involves regular follow-ups for months or even years after the procedure. Frequent blood tests are conducted to track blood counts, which indicate the transplant's effectiveness.
Reasons for Transplantation
- This type of transplant uses stem cells from an identical twin of the patient.
- This type of transplant uses the patient's own stem cells, which are collected and stored before high-dose treatments.
Syngeneic
Autologous
- This type of transplant uses stem cells from a donor who is not genetically identical to the patient. The donor can be a related family member or an unrelated individual with matching human leukocyte antigens (HLA).
Allogeneic
Types of Transplants
- Collected before high-dose chemotherapy or radiation. Used in multiple myeloma, some lymphomas
Autologous:
Using the patient’s own stem cells
- From a family member, unrelated donor. Used in leukemia, genetic diseases
Allogeneic:
Using donor’s stem cells
- Parent, child, or sibling with 50% match. Widens donor pool for those without full matches
Haploidentical:
Using half-matched family donor
Stem Cell Sources
Peripheral blood
Most common, cells mobilized from marrow to blood
Bone marrow
Extracted from hip bones under anesthesia
Transplant Process
- Tests to assess health and find a donor.
- High-dose chemotherapy/radiation to destroy diseased marrow.
Pre-transplant
- Infusion of stem cells through IV (like a blood transfusion)
- Cells travel to bone marrow and start producing new blood cells
Transplant
- 2-4 weeks for new marrow to produce enough cells
- Anti-rejection drugs for allogeneic transplants
Post-transplant
Transforming Lives Through Blood & Marrow Transplants(BMT)
Our Centre for Transplantation (BMT) & cellular therapy has a proven track record of success in performing blood & marrow transplants for a variety of conditions, including:
Our Achievements
- Extensive experience treating benign blood disorders and primary immunodeficiencies.
- Treatment of all types of pediatric cancers including blood disorders and solid tumors.
- Performed one of the largest cohorts of Hepatoblastoma treatments to date.
- Conduct various transplant types, including advanced procedures like T-cell depleted haploidentical transplants.
- Completed over 700+ transplants in 10 years with an 80%+ success rate.
Our Expert Care Team
Dr Vimal Kumar G
Paediatric
Senior Consultant
Paediatric Haematology, Oncology, Blood and Marrow Transplantation
Dr. Vimal Kumar G serves as a Senior Consultant in Paediatric Haematology, Oncology, Blood and Marrow Transplantation. His expertise focuses on diagnosing and treating blood disorders and cancers in children. Dr. Kumar specializes in advanced treatments including bone marrow transplantation. As a senior member of the team, he likely plays a key role in patient care, research, and mentoring junior staff in this complex field of pediatric medicine.
Dr Rishab Bharadwaj
Paediatric
Consultant
Paediatric Haematology, Oncology, Blood and Marrow Transplantation
Dr Gopinathan M is an Associate Consultant in the Department of Oncology (Division – Hematology). He provides comprehensive care to patients with Hematologic Malignancies with sensitivity and dedication. Among the conditions he treats are acute Leukaemias, Multiple Myeloma, Hodgkin’s and Non Hodgkin’s lymphoma, Chronic Lympho proliferative disorders and other Blood Dyscrasias that can be cured through transplantation. He is involved in performing Autologous and Allogeneic Hematopoietic stem cell transplantation and is keen on giving long term post transplant care for his patients.
Dr Gopinathan
Adult
Consultant
Haemato-Oncology & Bone Marrow Transplantation
Dr Gopinathan M is an Consultant in the Department of Oncology (Division – Hematology). He provides comprehensive care to patients with Hematologic Malignancies with sensitivity and dedication. Among the conditions he treats are acute Leukaemias, Multiple Myeloma, Hodgkin’s and Non Hodgkin’s lymphoma, Chronic Lympho proliferative disorders and other Blood Dyscrasias that can be cured through transplantation. He is involved in performing Autologous and Allogeneic Hematopoietic stem cell transplantation and is keen on giving long term post transplant care for his patients.
Dr M Deenadayalan
Paediatric
HOD and Clinical Lead
Paediatric Haematology, Oncology, Blood and Marrow Transplantation
Dr. M Deenadayalan leads the Paediatric Haematology, Oncology, Blood and Marrow Transplantation department at MGM Cancer Institute. As Head of Department and Clinical Lead, he specializes in treating childhood blood disorders and cancers. His expertise includes bone marrow transplantation, a critical procedure for many young patients. Dr. Deenadayalan's role combines clinical care, research, and leadership in pediatric oncology.